GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs6919210 | 1 | rs62420119 | chr6:70583953 | COL19A1 | chr6:70576448-70922157:+ | -0.28 | -4.31 | 2.0E-5 | Subjective well-being |
| THCA | cis | rs956096 | 1 | rs62427470 | chr6:155910279 | TFB1M | chr6:155578791-155635626:- | 0.23 | 3.36 | 0.000845 | Schizophrenia |
| THCA | cis | rs848490 | 1 | rs62460739 | chr7:77406747 | PTPN12 | chr7:77166773-77269388:+ | -0.17 | -3.84 | 0.00014 | Glomerular filtration rate (creatinine);Glomerular filtration rate in non diabetics (creatinine) |
| THCA | cis | rs848490 | 1 | rs62460739 | chr7:77406747 | RSBN1L | chr7:77325743-77409120:+ | 0.15 | 3.66 | 0.000284 | Glomerular filtration rate (creatinine);Glomerular filtration rate in non diabetics (creatinine) |
| THCA | cis | rs848490 | 1 | rs62460740 | chr7:77409439 | PTPN12 | chr7:77166773-77269388:+ | -0.17 | -3.72 | 0.000222 | Glomerular filtration rate (creatinine);Glomerular filtration rate in non diabetics (creatinine) |
| THCA | cis | rs848490 | 1 | rs62460740 | chr7:77409439 | RSBN1L | chr7:77325743-77409120:+ | 0.14 | 3.47 | 0.000561 | Glomerular filtration rate (creatinine);Glomerular filtration rate in non diabetics (creatinine) |
| THCA | cis | rs9638182 | 1 | rs62465144 | chr7:72883106 | MLXIPL | chr7:73007524-73038870:- | 0.21 | 3.93 | 9.6E-5 | Triglycerides |
| THCA | cis | rs801193 | 1 | rs62466793 | chr7:66191517 | GUSB | chr7:65425675-65447246:- | 0.34 | 6.84 | 2.39E-11 | Aortic root size |
| THCA | cis | rs801193 | 1 | rs62466793 | chr7:66191517 | RABGEF1 | chr7:66093890-66276446:+ | 0.52 | 10.68 | 5.06E-24 | Aortic root size |
| THCA | cis | rs801193 | 1 | rs62466793 | chr7:66191517 | TYW1 | chr7:66461817-66704496:+ | 0.18 | 3.88 | 0.000118 | Aortic root size |
| THCA | cis | rs801193 | 1 | rs62466794 | chr7:66191579 | GUSB | chr7:65425675-65447246:- | 0.33 | 6.71 | 5.64E-11 | Aortic root size |
| THCA | cis | rs801193 | 1 | rs62466794 | chr7:66191579 | RABGEF1 | chr7:66093890-66276446:+ | 0.51 | 10.5 | 2.42E-23 | Aortic root size |
| THCA | cis | rs801193 | 1 | rs62466794 | chr7:66191579 | TYW1 | chr7:66461817-66704496:+ | 0.18 | 3.96 | 8.55E-5 | Aortic root size |
| THCA | cis | rs3745672 | 1 | rs624976 | chr19:12110238 | ZNF763 | chr19:12035900-12091196:+ | 0.36 | 4.61 | 5.19E-6 | Multiple sclerosis |
| THCA | cis | rs6988636 | 1 | rs62521826 | chr8:124186668 | FAM83A | chr8:124191287-124222317:+ | -0.34 | -4.22 | 2.89E-5 | Urinary uromodulin levels |